gene_symbol
IL5RA
hgnc_id
HGNC:6017
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Benralizumab binds IL-5Rα on eosinophils/basophils and engages NK cells via its afucosylated Fc (FcγRIIIa), triggering potent ADCC that lyses/induces apoptosis of IL-5Rα+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Target highly expressed on eosinophils and basophils; afucosylated IgG1 Fc enhances ADCC via NK cell Fc gamma RIIIa
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05273359
disease_id_num_tar_ref
5250
drug_id_num_tar_ref
14267