gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds Trop-2, is internalized, and releases SN-38; the payload inhibits topoisomerase I, stabilizing Topo I–DNA complexes to cause DNA damage and apoptosis, with a membrane-permeable bystander effect.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ADC payload (SN-38) target
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06878625
disease_id_num_tar_ref
5251
drug_id_num_tar_ref
14268