gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Teclistamab binds CD3 on T cells and BCMA on myeloma cells to form an immune synapse, activating TCR signaling and T cell perforin/granzyme killing of BCMA-positive tumor cells; CD3-expressing T cells are effectors, not targets.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Trial text specifies CD3; typical binder is the CD3 epsilon subunit
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06425991
disease_id_num_tar_ref
5252
drug_id_num_tar_ref
14272