gene_symbol
MS4A1
hgnc_id
HGNC:7315
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Glofitamab bridges CD3+ T cells to CD20+ cells, activating T-cell cytotoxicity that kills the CD20-expressing cells via perforin/granzyme-mediated lysis (and related effector pathways).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
B-cell surface antigen; 2:1 bispecific format favors CD20 engagement
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06047080
disease_id_num_tar_ref
5269
drug_id_num_tar_ref
14329