gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Engineered TCR-T cells recognize the HPV16 E7 peptide–HLA-A*02:01 complex via their TCR and kill target cells through perforin/granzyme-mediated cytolysis (and Fas–FasL apoptosis) after activation.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
peptide–MHC class I (pMHC) complex; HLA-A*02:01 restricted
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06358053
disease_id_num_tar_ref
49
drug_id_num_tar_ref
121