gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds CD79b on B cells, is internalized, and releases MMAE, which binds beta-tubulin to block microtubule polymerization, causing mitotic arrest and apoptosis. Beta-tubulin expression alone is not sufficient; only CD79b+ cells are killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Payload MMAE binds the vinca domain to inhibit polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06047080
disease_id_num_tar_ref
5269
drug_id_num_tar_ref
14330