gene_symbol
IFNGR1
hgnc_id
HGNC:5439
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
MASCT-I expands tumor antigen–specific T cells that kill antigen-presenting tumor cells via perforin/granzyme (±Fas/FasL). IFN-γ signals through IFNGR1 to modulate cells, but IFNGR1-expressing cells are not directly targeted for killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Activated effector T cells secrete IFN-γ that binds IFNGR1/2 on target/immune cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06277154
disease_id_num_tar_ref
5273
drug_id_num_tar_ref
14344