gene_symbol
IFNGR2
hgnc_id
HGNC:5440
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
DCs prime tumor‑specific T cells, and infused effector T cells kill cells presenting tumor antigens via TCR recognition and perforin/granzyme release; IFN-γ signaling via IFNGR2 modulates responses but does not make IFNGR2+ cells direct targets.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Activated effector T cells secrete IFN-γ that binds IFNGR1/2 on target/immune cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06277154
disease_id_num_tar_ref
5273
drug_id_num_tar_ref
14344