gene_symbol
CD38
hgnc_id
HGNC:1667
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD38 IgG1 binds CD38 on target cells and elicits Fc-mediated ADCC (NK cells), ADCP (phagocytes), complement-dependent cytotoxicity, and can trigger direct apoptotic signaling.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface type II transmembrane ectoenzyme (NADase/cyclase)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06253637
disease_id_num_tar_ref
5276
drug_id_num_tar_ref
14349