gene_symbol
MSLN
hgnc_id
HGNC:7371
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-mesothelin CAR-T cells bind mesothelin on target cells and, upon activation, kill them via T-cell cytotoxicity (perforin/granzyme release and death-receptor–mediated apoptosis).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Membrane-bound mesothelin on tumor cells (GPI-anchored)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05848999
disease_id_num_tar_ref
5281
drug_id_num_tar_ref
14369