gene_symbol
EPHA2
hgnc_id
HGNC:3386
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The vaccine primes HLA-A*0201–restricted EphA2-specific CD8+ T cells, which recognize EphA2-derived peptide–MHC I on tumor cells and kill them via perforin/granzyme (and Fas–FasL) cytotoxicity.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
HLA-A*0201–restricted CD8 epitope
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05283109
disease_id_num_tar_ref
5285
drug_id_num_tar_ref
14379