gene_symbol
SIGLEC2
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The anti-CD22 ADC binds CD22, is internalized, and releases calicheamicin, which binds the DNA minor groove causing double-strand breaks and apoptosis in target cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ADC antigen; internalizing B-cell receptor
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05865301
disease_id_num_tar_ref
5289
drug_id_num_tar_ref
14389