gene_symbol
UNKNOWN
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Inotuzumab ozogamicin targets CD22 on B cells, is internalized, and releases calicheamicin, which binds the DNA minor groove to cause double-strand breaks and apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ADC payload target (calicheamicin)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05865301
disease_id_num_tar_ref
5289
drug_id_num_tar_ref
14389