gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Pertuzumab binds HER2, blocks HER2/HER3 signaling to trigger apoptosis, and its IgG1 Fc engages FcγR+ effector cells (e.g., NK cells) to mediate ADCC (±CDC), killing HER2+ cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular subdomain II (dimerization domain); blocks HER2 heterodimerization, especially with HER3
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05730712
disease_id_num_tar_ref
5297
drug_id_num_tar_ref
14413