gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The anti-HER2 ADC binds HER2, is internalized, and releases MMAE intracellularly via a cleavable linker; MMAE inhibits microtubule polymerization, causing G2/M arrest and apoptosis (with a membrane-permeable payload enabling bystander killing).
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Extracellular domain epitope on tumor cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05661357
disease_id_num_tar_ref
5300
drug_id_num_tar_ref
14422