gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds CD79b on B cells, is internalized, and releases MMAE; MMAE binds beta-tubulin to disrupt microtubules, causing G2/M arrest and apoptosis in CD79b-positive cells, not in cells merely expressing beta-tubulin.
enzyme_product
Off
epitope
Off
variant
Off
isoform
On
hla_specific
Off
gated
Off
other_modifier
MMAE binds the vinca-binding site on beta-tubulin; multiple beta-tubulin isotypes may be engaged (e.g., TUBB, TUBB2A, TUBB3)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06664411
disease_id_num_tar_ref
5308
drug_id_num_tar_ref
14436