gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
HER2-specific CAR-T cells bind HER2 on target cells and, upon activation, kill them via perforin/granzyme-mediated cytolysis (and death receptor pathways).
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
extracellular domain
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06101082
disease_id_num_tar_ref
5311
drug_id_num_tar_ref
14445