gene_symbol
ULBP4
binding_type
receptor ligand recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
NKG2D-CAR T cells recognize ULBP4 on target cells, triggering CAR signaling and T-cell cytotoxicity via immune synapse formation with perforin/granzyme release (and Fas/FasL), inducing apoptosis of the target cell.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Stress-induced NKG2D ligand on tumor cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06087341
disease_id_num_tar_ref
5319
drug_id_num_tar_ref
14474