gene_symbol
KRAS
hgnc_id
HGNC:6407
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Engineered TCR-T cells recognize the KRAS G12V peptide presented by HLA-A*11:01 and directly kill target cells via TCR-triggered cytolysis (perforin/granzyme and Fas/FasL-mediated apoptosis).
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Presented in complex with HLA-A*11:01 (MHC class I); TCR recognizes the peptide–HLA complex
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06545201
disease_id_num_tar_ref
5323
drug_id_num_tar_ref
14490