gene_symbol
HLA-A
hgnc_id
HGNC:4931
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Engineered TCR-T cells directly lyse cells only when they present the KRAS G12V peptide in HLA-A*11:01 via perforin/granzyme-mediated killing; HLA-A*11:01 expression alone is not sufficient.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Allele restriction for presentation of KRAS G12V peptide; TCR binding is specific to peptide–HLA complex
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06545201
disease_id_num_tar_ref
5323
drug_id_num_tar_ref
14490