gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Infused TILs recognize tumor-associated peptide-HLA class I complexes via their native TCRs and directly kill the target cell through cytolytic granule release (perforin/granzyme) and Fas-FasL–mediated apoptosis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
CD8+ TCR recognition of non-mutated TAAs (e.g., cancer-testis or lineage antigens) bound to HLA-A/B/C
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06541327
disease_id_num_tar_ref
5328
drug_id_num_tar_ref
14505