gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Teclistamab binds CD3 on T cells to recruit/activate them; the activated T cells kill BCMA-positive myeloma cells via perforin/granzyme cytotoxicity. CD3+ cells are not the targets of killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
T-cell receptor/CD3 complex component
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06477783
disease_id_num_tar_ref
5330
drug_id_num_tar_ref
14511