gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Bel-sar binds HSPGs on tumor cells; near-infrared light activates the IR700 photosensitizer to generate ROS and cause photochemical membrane damage, leading to rapid necrotic/immunogenic cell death.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds primarily to the heparan sulfate glycosaminoglycan chains on tumor cell-surface proteoglycans; relevant core proteins include syndecans (SDC1–4) and glypicans (GPC1–6).
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06007690
disease_id_num_tar_ref
5331
drug_id_num_tar_ref
14512