gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Bispecific ADC binds EGFR (and c-MET) on tumor cells, is internalized, and releases a topoisomerase I inhibitor that stabilizes TOP1–DNA cleavable complexes, causing DNA breaks, cell-cycle arrest, and apoptosis.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface receptor tyrosine kinase; extracellular-domain binding by ADC antibody arm leading to internalization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06366451
disease_id_num_tar_ref
5332
drug_id_num_tar_ref
14516