gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
This CAR T therapy targets CD19, killing CD19+ cells via T‑cell cytotoxicity (perforin/granzyme). EGFR is only a truncated tag (huEGFRt) on the CAR T cells for selection/depletion and is not a cytotoxic target; EGFR+ cells are not targeted.
enzyme_product
On
epitope
Off
variant
Off
isoform
On
hla_specific
Off
gated
Off
other_modifier
Truncated human EGFR (huEGFRt) safety/selection tag enabling tracking or antibody-mediated depletion
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06378190
disease_id_num_tar_ref
454
drug_id_num_tar_ref
1275