gene_symbol
ITGB3
hgnc_id
HGNC:6156
binding_type
receptor ligand recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The RGD-modified adenovirus uses αvβ3 (integrin β3-containing) for entry; in COX-2–overexpressing cells it replicates and causes lytic oncolysis, directly killing the infected cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Beta subunit forming αvβ3 heterodimer with ITGAV; RGD-binding receptor for viral entry
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06693986
disease_id_num_tar_ref
5338
drug_id_num_tar_ref
14530