gene_symbol
ITGB5
hgnc_id
HGNC:6160
binding_type
receptor ligand recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
RGD-modified adenovirus binds alpha v beta 5 integrin for entry; in COX-2–overexpressing cells, COX-2–driven E1 expression enables viral replication and lytic oncolysis, directly killing the infected cell.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Beta subunit forming αvβ5 heterodimer with ITGAV; RGD-binding receptor for viral entry
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06693986
disease_id_num_tar_ref
5338
drug_id_num_tar_ref
14530