gene_symbol
MS4A1
hgnc_id
HGNC:7315
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Antibody binds CD20 on B cells and triggers complement-dependent cytotoxicity and Fc-mediated effector killing (ADCC by NK cells and ADCP by macrophages), leading to lysis/phagocytosis of CD20+ cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Membrane-proximal epitope on the extracellular loops of CD20 on B cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06167642
disease_id_num_tar_ref
5340
drug_id_num_tar_ref
14533