gene_symbol
STEAP2
hgnc_id
HGNC:17885
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
STEAP2-specific CAR T cells bind STEAP2 on target cells and directly kill them via T-cell cytotoxic mechanisms (perforin/granzyme-mediated lysis and death receptor apoptosis); dnTGFBRII enhances activity by blocking TGF-β suppression.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
cell-surface metalloreductase antigen on prostate cancer cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06267729
disease_id_num_tar_ref
5349
drug_id_num_tar_ref
14553