gene_symbol
TGFB1
hgnc_id
HGNC:11766
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Cells expressing TGF-β1 are not directly targeted. AZD0754 CAR T cells kill STEAP2-positive tumor cells via perforin/granzyme-mediated cytolysis; the dnTGFβRII arm only blocks TGF-β signaling in the CAR T cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
bound by dominant-negative TGFBR2 (dnTGFBRII) armor on CAR T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06267729
disease_id_num_tar_ref
5349
drug_id_num_tar_ref
14553