gene_symbol
TACSTD2
hgnc_id
HGNC:11530
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds TROP2 on target cells, is internalized, and releases SN-38 intracellularly; SN-38 inhibits topoisomerase I, causing DNA breaks and apoptosis in TROP2-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Membrane glycoprotein target for antibody component (hRS7)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06238921
disease_id_num_tar_ref
456
drug_id_num_tar_ref
1283