gene_symbol
TGFB3
hgnc_id
HGNC:11769
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
TGF-β3 is not the CAR target. The dnTGFβRII only blocks TGF-β signaling in the CAR T cells. Killing is directed to STEAP2-positive cells via CAR T cell cytotoxicity (perforin/granzyme-mediated lysis).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
bound by dominant-negative TGFBR2 (dnTGFBRII) armor on CAR T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06267729
disease_id_num_tar_ref
5349
drug_id_num_tar_ref
14553