gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR T cells bind CD19 on target cells, become activated via CD28/CD3ΞΆ signaling, and kill the CD19+ cells through perforin/granzyme-mediated cytolysis (and Fas/FasL), with supportive cytokine-driven effects.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05625594
disease_id_num_tar_ref
5359
drug_id_num_tar_ref
14579