gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
This therapy’s CAR targets CD19 to kill CD19+ cells. The EGFRt tag is a safety/tracking marker enabling optional ablation of the CAR T cells with cetuximab; it does not mediate killing of EGFR-expressing cells by this product.
enzyme_product
On
epitope
On
variant
On
isoform
On
hla_specific
Off
gated
Off
other_modifier
Safety/tracking tag enabling cetuximab-mediated depletion; not the tumor antigen targeted by the CAR
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05625594
disease_id_num_tar_ref
5359
drug_id_num_tar_ref
14579