gene_symbol
CD44
hgnc_id
HGNC:1681
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds CD44v9, is internalized, and lysosomal linker cleavage releases a topoisomerase I inhibitor (KL610023) that inhibits Top1, causing replication-associated DNA damage and apoptosis of CD44v9+ cells (with possible bystander effect).
enzyme_product
Off
epitope
On
variant
On
isoform
On
hla_specific
Off
gated
Off
other_modifier
Tumor-associated cell-surface antigen; splice variant-specific epitope
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06782334
disease_id_num_tar_ref
5360
drug_id_num_tar_ref
14582