gene_symbol
KIT
hgnc_id
HGNC:6342
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
By binding CD117 (c-KIT) and blocking SCF–c-KIT survival signaling, it depletes c-KIT–dependent cells (e.g., HSCs, mast cells), leading to apoptosis/loss of viability; Fc effector functions may also contribute to immune-mediated clearance.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Blocks stem cell factor (SCF/KITLG) binding to KIT, inhibiting SCF–KIT signaling
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06353971
disease_id_num_tar_ref
52
drug_id_num_tar_ref
127