gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Peptide vaccine is taken up by dendritic cells and presented on HLA-A2, priming/expanding TAA-specific CD8+ T cells (with CD4 Th1 help). Activated CTLs then recognize HLA-A2–restricted TAA peptides on tumor cells and kill them via perforin/granzyme-mediated cytotoxicity.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Onco-mimic peptides derived from human gut microbiome; mimic TAAs on colorectal cancer cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05350501
disease_id_num_tar_ref
5370
drug_id_num_tar_ref
14613