gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
SN-38 released from the ADC binds and inhibits topoisomerase I, stabilizing topo I–DNA complexes and causing DNA damage and apoptosis (after delivery via Trop-2 targeting or bystander diffusion).
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
intracellular enzymatic target of SN-38 payload
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06100874
disease_id_num_tar_ref
5402
drug_id_num_tar_ref
14694