gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Trastuzumab binds HER2 and engages Fcγ receptor–bearing effector cells (e.g., NK cells) to mediate ADCC, killing HER2-expressing cells.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain to block receptor dimerization and enable ADCC via Fcγ receptor–bearing immune cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06100874
disease_id_num_tar_ref
5402
drug_id_num_tar_ref
14695