gene_symbol
TACSTD2
hgnc_id
HGNC:11530
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds TROP-2, is internalized, and releases SN-38 that inhibits topoisomerase I, causing DNA damage, cell-cycle arrest, and apoptosis (with a bystander effect).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface antigen targeted by the ADC for internalization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT07251868
disease_id_num_tar_ref
5403
drug_id_num_tar_ref
14697