gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Cetuximab binds EGFR and its IgG1 Fc engages FcγR-bearing effector cells (e.g., NK cells) to mediate ADCC (and possibly CDC), killing EGFR+ cells; it also blocks EGFR signaling to inhibit proliferation.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain to block ligand binding and receptor dimerization; IgG1 Fc can mediate ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06586515
disease_id_num_tar_ref
5407
drug_id_num_tar_ref
14703