gene_symbol
BCL2
hgnc_id
HGNC:990
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Venetoclax directly inhibits BCL-2, freeing pro-apoptotic effectors to activate BAX/BAK, causing mitochondrial outer membrane permeabilization and caspase-dependent apoptosis in BCL-2–dependent cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
BH3-groove binding (BH3 mimetic) inhibitor of anti-apoptotic BCL-2
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05553782
disease_id_num_tar_ref
5411
drug_id_num_tar_ref
14719