gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds HER2, is internalized, and releases MMAE, which inhibits microtubule polymerization causing G2/M arrest and apoptosis; Fc-mediated ADCC may also contribute.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface receptor; antibody-mediated internalization and potential ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06492317
disease_id_num_tar_ref
5412
drug_id_num_tar_ref
14724