gene_symbol
CLEC12A
hgnc_id
HGNC:31713
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR-NK cells bind CLL1 (CLEC12A) on target cells, triggering NK activation and degranulation (perforin/granzyme) leading to apoptotic/lytic killing, with additional cytokine-mediated cytotoxicity.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Also known as CLL-1/MICL/CD371; myeloid inhibitory C-type lectin on AML blasts
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05987696
disease_id_num_tar_ref
5416
drug_id_num_tar_ref
14730