gene_symbol
TACSTD2
hgnc_id
HGNC:11530
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds TROP-2, is internalized, linker is cleaved to release SN-38 (topoisomerase I inhibitor), causing DNA damage, replication arrest, and apoptosis; released payload can also cause a bystander effect.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface transmembrane glycoprotein; also known as EGP-1
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05609968
disease_id_num_tar_ref
5423
drug_id_num_tar_ref
14743