gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC does not bind topoisomerase I; it binds TROP-2, is internalized, and releases SN-38, which inhibits DNA topoisomerase I, stabilizing cleavage complexes and causing DNA breaks and apoptosis (with possible bystander effect).
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Target of payload SN-38 (irinotecan active metabolite)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05609968
disease_id_num_tar_ref
5423
drug_id_num_tar_ref
14743