gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Tucatinib directly inhibits the HER2 tyrosine kinase, blocking PI3K/AKT and MAPK signaling, leading to growth arrest and apoptosis of HER2-expressing tumor cells.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Intracellular kinase domain (ATP-binding site)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT04789096
disease_id_num_tar_ref
5430
drug_id_num_tar_ref
14755