gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Trastuzumab binds HER2 on target cells and recruits FcγR-expressing immune effectors (e.g., NK cells) to mediate antibody-dependent cellular cytotoxicity (ADCC), with possible complement-dependent cytotoxicity (CDC).
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds subdomain IV of the HER2 extracellular domain; inhibits receptor activation and mediates ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT04789096
disease_id_num_tar_ref
5430
drug_id_num_tar_ref
14756