gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
IBI354 binds HER2 on tumor cells, is internalized, and releases a topoisomerase I–inhibiting payload that causes DNA damage and apoptosis; killing is driven by HER2 targeting, not by Topoisomerase I expression itself.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Intracellular payload target (camptothecin-derived TOP1 inhibitor)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05636215
disease_id_num_tar_ref
5436
drug_id_num_tar_ref
14773