gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CD19-specific CAR T cells bind CD19 on target cells, activating CD3zeta/4-1BB signaling and inducing T-cell cytolysis via perforin/granzyme release and death-receptor pathways, leading to apoptosis/lysis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Membrane B-cell antigen; extracellular domain recognized by CAR scFv
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06762431
disease_id_num_tar_ref
5450
drug_id_num_tar_ref
14805